Personally, this book changed my life, and helped shift perspectives for me. It is not enough to feel discontent with our lives. As people who do and make thinks (even thinking is making new realities), humans need to know where to go next, we need a sense of direction. It is also not enough to say "include indigenous thinking in our culture, in our society". We have to know indigenous culture, and indigenous history. As an indigenous botanist, Robin Wall Kimmerer associates her knowledge of plants and trees, of the land and the soil, of the climate and the biosphere, of ecosystems with the ancestral knowledge of her people and the Indigenous Nations' wisdom. This is such a ground-breaking book that the care with which it was written is almost like a love letter to what the author calls Mother Nature. At first I didn't like that appellation: why Mother? Don't we know that not all women want to be mothers? Why gendering? But then I understood that words and meanings are never literal but material and deep in indigenous culture: you can mother without birthing, for instance. It is about a special kind of care and nurturing. I am fine with that, even men can be mothers. This is my feminism and the feminism of the earth. I want all in the feminine realm, like the Earth wants all human beings interacting. 
About the latter: this is where this book is fascinating and breaks the mould of nature/culture: it explains how every animal and being is related to the growth and the organisation of life around them. Basket weaving reinforces the growth of Sweetgrass, ecosystems are fragile and strong. They will be powerful when we understand how everything works together and responds to one another. Human presence, like indigenous human presence, can be good in its intrusion in nature if there is an understanding of resources. It is explained how indigenous Nations know how to never take everything but half from nature, how they never take the first plant they see because it might be the last (they wait until the third if memory serves), etc.
There are so many teaching in this book that it would be impossible to list them all. But if there is one word that Wall Kimmerer choses to encompass her teachings, it's the work "reciprocity". It all comes from that: don't ask "what can this give me" but "what is this telling me?" and "what can I give back from what I took". This works for ecosystems but also for human relationships. It is, as it were, for me, the new ethics.